Ontology highlight
ABSTRACT:
SUBMITTER: Derecka M
PROVIDER: S-EPMC3522427 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Cell metabolism 20121201 6
Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expression of Tyk2 or the constitutively active form of the transcription factor Stat3 (CAStat3) restores differentiation in Tyk2(-/-) brown preadipocytes. Furthermore, Tyk2(-/-) mice expres ...[more]