Ontology highlight
ABSTRACT:
SUBMITTER: Badugu A
PROVIDER: S-EPMC3524521 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Badugu Amarendra A Kraemer Conradin C Germann Philipp P Menshykau Denis D Iber Dagmar D
Scientific reports 20121218
Turing models have been proposed to explain the emergence of digits during limb development. However, so far the molecular components that would give rise to Turing patterns are elusive. We have recently shown that a particular type of receptor-ligand interaction can give rise to Schnakenberg-type Turing patterns, which reproduce patterning during lung and kidney branching morphogenesis. Recent knockout experiments have identified Smad4 as a key protein in digit patterning. We show here that the ...[more]