Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC3593883 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Song Lei L Santos-Sacchi Joseph J
Proceedings of the National Academy of Sciences of the United States of America 20130219 10
Outer hair cells (OHCs) drive cochlear amplification that enhances our ability to detect and discriminate sounds. The motor protein, prestin, which evolved from the SLC26 anion transporter family, underlies the OHC's voltage-dependent mechanical activity (eM). Here we report on simultaneous measures of prestin's voltage-sensor charge movement (nonlinear capacitance, NLC) and eM that evidence disparities in their voltage dependence and magnitude as a function of intracellular chloride, challengin ...[more]