Voltage sensor gating charge transfer in a hERG potassium channel model.
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ABSTRACT:
SUBMITTER: Colenso CK
PROVIDER: S-EPMC4241455 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Publications
Voltage sensor gating charge transfer in a hERG potassium channel model.
Colenso Charlotte K CK Cao Yang Y Sessions Richard B RB Hancox Jules C JC Dempsey Christopher E CE
Biophysical journal 20141101 10
Relaxation of a hERG K(+) channel model during molecular-dynamics simulation in a hydrated POPC bilayer was accompanied by transitions of an arginine gating charge across a charge transfer center in two voltage sensor domains. Inspection of the passage of arginine side chains across the charge transfer center suggests that the unique hydration properties of the arginine guanidine cation facilitates charge transfer during voltage sensor responses to changes in membrane potential, and underlies th ...[more]
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