Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC3616429 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Zhao Ying Y Li Xue X Cai Mu-Yan MY Ma Ke K Yang Jing J Zhou Jingyi J Fu Wan W Wei Fu-Zheng FZ Wang Lina L Xie Dan D Zhu Wei-Guo WG
Cell research 20130101 4
Autophagy is activated to maintain cellular energy homeostasis in response to nutrient starvation. However, autophagy is not persistently activated, which is poorly understood at a mechanistic level. Here, we report that turnover of FoxO1 is involved in the dynamic autophagic process caused by glutamine starvation. X-box-binding protein-1u (XBP-1u) has a critical role in FoxO1 degradation by recruiting FoxO1 to the 20S proteasome. In addition, the phosphorylation of XBP-1u by extracellular regul ...[more]