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A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.

ABSTRACT: A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.

SUBMITTER: Yoon W

PROVIDER: S-EPMC3652654 | biostudies-other | 2010 Jan

REPOSITORIES: biostudies-other

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A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.

Yoon Woohyun W Ma Ben-Jiang BJ Fellay Jacques J Huang Wei W Xia Shi-Mao SM Zhang Ruijun R Shianna Kevin V KV Liao Hua-Xin HX Haynes Barton F BF Goldstein David B DB

AIDS (London, England) 20100101 1

A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional var ...[more]

PMID: 19935381

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