Unknown

Dataset Information

0

Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012.


ABSTRACT: Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn²? complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.

SUBMITTER: Liu N 

PROVIDER: S-EPMC3707159 | biostudies-other | 2013 May

REPOSITORIES: biostudies-other

altmetric image

Publications

Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012.

Liu Ning N   Shang Fei F   Xi Lijun L   Huang Ying Y  

Marine drugs 20130510 5


Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyoche  ...[more]

Similar Datasets

| S-EPMC6521030 | biostudies-literature
| S-EPMC3928670 | biostudies-literature
| S-EPMC4603692 | biostudies-literature
| S-EPMC7824713 | biostudies-literature
| S-EPMC3266378 | biostudies-literature
| S-EPMC6780507 | biostudies-literature
| S-EPMC4012447 | biostudies-literature
| S-EPMC9147834 | biostudies-literature
| S-EPMC8622039 | biostudies-literature
| S-EPMC4393426 | biostudies-literature