Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC3753872 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Wang Ping P Luo Yongting Y Duan Hongxia H Xing Shu S Zhang Jianlin J Lu Di D Feng Jing J Yang Dongling D Song Lina L Yan Xiyun X
Molecular and cellular biology 20130722 18
CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain unclear. Using a microRNA screening approach, we identified a novel negative regulator of angiogenesis, microRNA 329 (miR-329), that directly targeted CD146 and inhibited CD146-mediated ...[more]