Ontology highlight
ABSTRACT:
SUBMITTER: Al-Hilal TA
PROVIDER: S-EPMC4811144 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Al-Hilal Taslim A TA Chung Seung Woo SW Choi Jeong Uk JU Alam Farzana F Park Jooho J Kim Seong Who SW Kim Sang Yoon SY Ahsan Fakhrul F Kim In-San IS Byun Youngro Y
The Journal of clinical investigation 20160307 4
Controlled and site-specific regulation of growth factor signaling remains a major challenge for current antiangiogenic therapies, as these antiangiogenic agents target normal vasculature as well tumor vasculature. In this article, we identified the prion-like protein doppel as a potential therapeutic target for tumor angiogenesis. We investigated the interactions between doppel and VEGFR2 and evaluated whether blocking the doppel/VEGFR2 axis suppresses the process of angiogenesis. We discovered ...[more]