Ontology highlight
ABSTRACT:
SUBMITTER: Gaglia G
PROVIDER: S-EPMC3780836 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Gaglia Giorgio G Guan Yinghua Y Shah Jagesh V JV Lahav Galit G
Proceedings of the National Academy of Sciences of the United States of America 20130904 38
Homo-oligomerization is found in many biological systems and has been extensively studied in vitro. However, our ability to quantify and understand oligomerization processes in cells is still limited. We used fluorescence correlation spectroscopy and mathematical modeling to measure the dynamics of the tetramers formed by the tumor suppressor protein p53 in single living cells. Previous in vitro studies suggested that in basal conditions all p53 molecules are bound in dimers. We found that in re ...[more]