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EGFR gets in the way of microRNA biogenesis.


ABSTRACT: Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.

SUBMITTER: Nishida N 

PROVIDER: S-EPMC3790241 | biostudies-other | 2013 Oct

REPOSITORIES: biostudies-other

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