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MicroRNA biogenesis pathways in cancer.

ABSTRACT: MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.

SUBMITTER: Lin S

PROVIDER: S-EPMC4859809 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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MicroRNA biogenesis pathways in cancer.

Lin Shuibin S Gregory Richard I RI

Nature reviews. Cancer 20150601 6

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highli ...[more]

PMID: 25998712

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Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila

Project description:Ago1-IP small RNA sequencing from S2R+ cells, with dsRNA knockdown of Dicer1 (and GFP control) One Dicer knockdown sample and one GFP knockdown control.

2013-12-04 | E-GEOD-51585 | biostudies-arrayexpress

Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila

Project description:Ago1-IP small RNA sequencing from S2R+ cells, with dsRNA knockdown of Dicer1 (and GFP control)

2013-12-04 | GSE51585 | GEO

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