Ontology highlight
ABSTRACT:
SUBMITTER: Brochier C
PROVIDER: S-EPMC3805873 | biostudies-other | 2013 Oct
REPOSITORIES: biostudies-other
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20131001 4
The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. Neurons, due to their post-mitotic state, high metabolism, and longevity are particularly prone to the accumulation of DNA lesions. Indeed, DNA damage has been suggested as a major contributor to both age-associated neurodegenerative diseases and acute neurological injury. The DNA damage response is a key factor in maintaining genome integrity. It relies on highly dynamic posttranslationa ...[more]