Ontology highlight
ABSTRACT:
SUBMITTER: Xie Y
PROVIDER: S-EPMC3892183 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Xie Yuqiong Y Li Qiang Q Yang Qingbo Q Yang Mei M Zhang Zhifeng Z Zhu Liucun L Yan Huang H Feng Ruili R Zhang Shiqing S Huang Chen C Liu Zengrong Z Wen Tieqiao T
Scientific reports 20140115
Gliomas are the most common brain tumors affecting the central nervous system and are associated with a high mortality rate. DCF1 is a membrane protein that was previously found to play a role in neural stem cell differentiation. In the present study, we found that overexpression of dcf1 significantly inhibited cell proliferation, migration, and invasion and dramatically promoted apoptosis in the glioblastoma U251 cell line. DCF1 deletion mutations in the functional region showed that the comple ...[more]