Ontology highlight
ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC3900798 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Yang Kai K Zhu Lei L Nie Liming L Sun Xiaolian X Cheng Liang L Wu Chenxi C Niu Gang G Chen Xiaoyuan X Liu Zhuang Z
Theranostics 20140102 2
Herein, we for the first time report a novel activatable photoacoustic (PA) imaging nano-probe for in vivo detection of cancer-related matrix metalloproteinases (MMPs). A black hole quencher 3 (BHQ3) which absorbs red light is conjugated to near-infrared (NIR)-absorbing copper sulfide (CuS) nanoparticles via a MMP-cleavable peptide linker. The obtained CuS-peptide-BHQ3 (CPQ) nano-probe exhibits two distinctive absorption peaks at 630 nm and 930 nm. Inside the tumor microenvironment where MMPs pr ...[more]