Ontology highlight
ABSTRACT:
SUBMITTER: Zapata J
PROVIDER: S-EPMC3912523 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Zapata Jessica J Dephoure Noah N Macdonough Tracy T Yu Yaxin Y Parnell Emily J EJ Mooring Meghan M Gygi Steven P SP Stillman David J DJ Kellogg Douglas R DR
The Journal of cell biology 20140201 3
Cell size checkpoints ensure that passage through G1 and mitosis occurs only when sufficient growth has occurred. The mechanisms by which these checkpoints work are largely unknown. PP2A associated with the Rts1 regulatory subunit (PP2A(Rts1)) is required for cell size control in budding yeast, but the relevant targets are unknown. In this paper, we used quantitative proteome-wide mass spectrometry to identify proteins controlled by PP2A(Rts1). This revealed that PP2A(Rts1) controls the two key ...[more]