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On the dephasing of genetic oscillators.

ABSTRACT: The digital nature of genes combined with the associated low copy numbers of proteins regulating them is a significant source of stochasticity, which affects the phase of biochemical oscillations. We show that unlike ordinary chemical oscillators, the dichotomic molecular noise of gene state switching in gene oscillators affects the stochastic dephasing in a way that may not always be captured by phenomenological limit cycle-based models. Through simulations of a realistic model of the NF?B/I?B network, we also illustrate the dephasing phenomena that are important for reconciling single-cell and population-based experiments on gene oscillators.

SUBMITTER: Potoyan DA

PROVIDER: S-EPMC3926054 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other

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On the dephasing of genetic oscillators.

Potoyan Davit A DA Wolynes Peter G PG

Proceedings of the National Academy of Sciences of the United States of America 20140127 6

The digital nature of genes combined with the associated low copy numbers of proteins regulating them is a significant source of stochasticity, which affects the phase of biochemical oscillations. We show that unlike ordinary chemical oscillators, the dichotomic molecular noise of gene state switching in gene oscillators affects the stochastic dephasing in a way that may not always be captured by phenomenological limit cycle-based models. Through simulations of a realistic model of the NFκB/IκB ...[more]

PMID: 24469814

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