Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice.
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ABSTRACT:
SUBMITTER: DiRaimondo TR
PROVIDER: S-EPMC3947056 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
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Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice.
DiRaimondo Thomas R TR Klöck Cornelius C Warburton Rod R Herrera Zachary Z Penumatsa Krishna K Toksoz Deniz D Hill Nicholas N Khosla Chaitan C Fanburg Barry B
ACS chemical biology 20131105 1
Previous studies in human patients and animal models have suggested that transglutaminase 2 (TG2) is upregulated in pulmonary hypertension (PH), a phenomenon that appears to be associated with the effects of serotonin (5-hydroxytryptamine; 5-HT) in this disease. Using chemical tools to interrogate and inhibit TG2 activity in vivo, we have shown that pulmonary TG2 undergoes marked post-translational activation in a mouse model of hypoxia-induced PH. We have also identified irreversible fluorinate ...[more]
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