Ontology highlight
ABSTRACT:
SUBMITTER: Workenhe ST
PROVIDER: S-EPMC3978812 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Workenhe Samuel T ST Simmons Graydon G Pol Jonathan G JG Lichty Brian D BD Halford William P WP Mossman Karen L KL
Molecular therapy : the journal of the American Society of Gene Therapy 20131009 1
Within the oncolytic virus field, the extent of virus replication that is essential for immune stimulation to control tumor growth remains unresolved. Using infected cell protein 0 (ICP0)-defective oncolytic Herpes simplex virus type 1 (HSV-1) and HSV-2 viruses (dICP0 and dNLS) that show differences in their in vitro replication and cytotoxicity, we investigated the inherent features of oncolytic HSV viruses that are required for potent antitumor activity. In vitro, the HSV-2 vectors showed rapi ...[more]