Ontology highlight
ABSTRACT:
SUBMITTER: Dvorak CA
PROVIDER: S-EPMC4025785 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Dvorak Curt A CA Liu Changlu C Shelton Jonathan J Kuei Chester C Sutton Steven W SW Lovenberg Timothy W TW Carruthers Nicholas I NI
ACS medicinal chemistry letters 20120611 8
Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-5-hydroxybenzoic acid 2, a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity. ...[more]