Ontology highlight
ABSTRACT:
SUBMITTER: Vance SA
PROVIDER: S-EPMC4038818 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Scientific reports 20140530
Diagnostic biomarkers (i.e. proteins) are often in low abundance in bodily fluids presenting many challenges for their detection. In order to extend the application of SPRi systems in detecting biomarkers at ultralow levels, we combine the advantage of aptamer technology with nanomaterials and microwave-assisted surface functionalization. By implementing a sandwich assay through the introduction of aptamer-modified quantum dots (QDs), it was possible to measure 7 zeptomole (at 5 fg/mL) of C-reac ...[more]