Ontology highlight
ABSTRACT:
SUBMITTER: Gupta R
PROVIDER: S-EPMC4121806 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Gupta Romi R Dong Yuying Y Solomon Peter D PD Wettersten Hiromi I HI Cheng Christopher J CJ Min Jin-Na JN Henson Jeremy J Dogra Shaillay Kumar SK Hwang Sung H SH Hammock Bruce D BD Zhu Lihua J LJ Reddel Roger R RR Saltzman W Mark WM Weiss Robert H RH Chang Sandy S Green Michael R MR Wajapeyee Narendra N
Proceedings of the National Academy of Sciences of the United States of America 20140714 30
Tumor suppressor p53 plays an important role in mediating growth inhibition upon telomere dysfunction. Here, we show that loss of the p53 target gene cyclin-dependent kinase inhibitor 1A (CDKN1A, also known as p21(WAF1/CIP1)) increases apoptosis induction following telomerase inhibition in a variety of cancer cell lines and mouse xenografts. This effect is highly specific to p21, as loss of other checkpoint proteins and CDK inhibitors did not affect apoptosis. In telomerase, inhibited cell loss ...[more]