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"PEST control": regulation of molecular barcodes by tyrosine phosphatases.


ABSTRACT: The emerging concept of "molecular barcodes" refers to the dynamic combination of post-translational modifications, often of different nature (e.g., phosphorylation and ubiquitination) that gives rise to multiple forms of a protein which can relay distinct signals throughout a cell. In a recent Cell Research paper by Wang et al., the authors report that a PEST domain-containing tyrosine phosphatase, PTPN18, is able to regulate both phosphorylation and ubiquitination of the HER2 oncogene, barcoding HER2 for increased proteasomal degradation rather than for intracellular trafficking.

SUBMITTER: Doody KM 

PROVIDER: S-EPMC4152731 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

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