Ontology highlight
ABSTRACT:
SUBMITTER: Beisang D
PROVIDER: S-EPMC4162518 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Beisang Daniel D Reilly Cavan C Bohjanen Paul R PR
Gene 20140811 1
Alternative polyadenylation (APA) is an evolutionarily conserved mechanism for regulating gene expression. Transcript 3' end shortening through changes in polyadenylation site usage occurs following T cell activation, but the consequences of APA on gene expression are poorly understood. We previously showed that GU-rich elements (GREs) found in the 3' untranslated regions of select transcripts mediate rapid mRNA decay by recruiting the protein CELF1/CUGBP1. Using a global RNA sequencing approach ...[more]