Ontology highlight
ABSTRACT:
SUBMITTER: Bretou M
PROVIDER: S-EPMC4196869 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Bretou Marine M Jouannot Ouardane O Fanget Isabelle I Pierobon Paolo P Larochette Nathanaël N Gestraud Pierre P Guillon Marc M Emiliani Valentina V Gasman Stéphane S Desnos Claire C Lennon-Duménil Ana-Maria AM Darchen François F
Molecular biology of the cell 20140820 20
Membrane fusion underlies multiple processes, including exocytosis of hormones and neurotransmitters. Membrane fusion starts with the formation of a narrow fusion pore. Radial expansion of this pore completes the process and allows fast release of secretory compounds, but this step remains poorly understood. Here we show that inhibiting the expression of the small GTPase Cdc42 or preventing its activation with a dominant negative Cdc42 construct in human neuroendocrine cells impaired the release ...[more]