Ontology highlight
ABSTRACT:
SUBMITTER: Soni MS
PROVIDER: S-EPMC4207388 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Soni Mufaddal S MS Rabaglia Mary E ME Bhatnagar Sushant S Shang Jin J Ilkayeva Olga O Mynatt Randall R Zhou Yun-Ping YP Schadt Eric E EE Thornberry Nancy A NA Muoio Deborah M DM Keller Mark P MP Attie Alan D AD
Diabetes 20140626 11
We previously demonstrated that micro-RNAs (miRNAs) 132 and 212 are differentially upregulated in response to obesity in two mouse strains that differ in their susceptibility to obesity-induced diabetes. Here we show the overexpression of miRNAs 132 and 212 enhances insulin secretion (IS) in response to glucose and other secretagogues including nonfuel stimuli. We determined that carnitine acyl-carnitine translocase (CACT; Slc25a20) is a direct target of these miRNAs. CACT is responsible for tra ...[more]