Ontology highlight
ABSTRACT:
SUBMITTER: Lee L
PROVIDER: S-EPMC4250909 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Lee Linda L Dale Elena E Staniszewski Agnes A Zhang Hong H Saeed Faisal F Sakurai Mikako M Fa' Mauro M Orozco Ian I Michelassi Francesco F Akpan Nsikan N Lehrer Helena H Arancio Ottavio O
Scientific reports 20141202
Learning and memory and the underlying cellular correlate, long-term synaptic plasticity, involve regulation by posttranslational modifications (PTMs). Here we demonstrate that conjugation with the small ubiquitin-like modifier (SUMO) is a novel PTM required for normal synaptic and cognitive functioning. Acute inhibition of SUMOylation impairs long-term potentiation (LTP) and hippocampal-dependent learning. Since Alzheimer's disease (AD) prominently features both synaptic and PTM dysregulation, ...[more]