Ontology highlight
ABSTRACT:
SUBMITTER: Diering GH
PROVIDER: S-EPMC4254581 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Diering Graham H GH Gustina Ahleah S AS Huganir Richard L RL
Neuron 20141023 4
Bidirectional synaptic plasticity occurs locally at individual synapses during long-term potentiation (LTP) or long-term depression (LTD), or globally during homeostatic scaling. LTP, LTD, and homeostatic scaling alter synaptic strength through changes in postsynaptic AMPA-type glutamate receptors (AMPARs), suggesting the existence of overlapping molecular mechanisms. Phosphorylation controls AMPAR trafficking during LTP/LTD. We addressed the role of AMPAR phosphorylation during homeostatic scal ...[more]