Ontology highlight
ABSTRACT:
SUBMITTER: Dermietzel R
PROVIDER: S-EPMC42976 | biostudies-other | 1994 Jan
REPOSITORIES: biostudies-other
Dermietzel R R Hwang T K TK Buettner R R Hofer A A Dotzler E E Kremer M M Deutzmann R R Thinnes F P FP Fishman G I GI Spray D C DC
Proceedings of the National Academy of Sciences of the United States of America 19940101 2
We have cloned a protein from bovine brain, brain-derived voltage-dependent anion channel 1 (BR1-VDAC), that is identical to a recently sequenced plasmalemmal-bound porin from human lymphocytes. mRNA hybridization indicates that BR1-VDAC is widely distributed throughout nervous and nonnervous tissues. In situ localization substantiated that the BR1-VDAC is associated with the plasmalemma of astrocytes. A monoclonal antibody that recognizes the N terminus of the BR1-VDAC protein completely blocks ...[more]