Ontology highlight
ABSTRACT:
SUBMITTER: Hong YK
PROVIDER: S-EPMC4322918 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Neuron 20141002 2
Mammalian sensory circuits become refined over development in an activity-dependent manner. Retinal ganglion cell (RGC) axons from each eye first map to their target in the geniculate and then segregate into eye-specific layers by the removal and addition of axon branches. Once segregation is complete, robust functional remodeling continues as the number of afferent inputs to each geniculate neuron decreases from many to a few. It is widely assumed that large-scale axon retraction underlies this ...[more]