Ontology highlight
ABSTRACT:
SUBMITTER: Tousi B
PROVIDER: S-EPMC4327563 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Neuropsychiatric disease and treatment 20150205
In 2012, a novel approach to the treatment of Alzheimer's disease was introduced, heralding a wave of excitement in the field of dementia. Bexarotene, a retinoid X receptor agonist, was shown to reverse neurodegeneration, improve cognition, and decrease levels of amyloid-β in transgenic mice expressing familial Alzheimer disease mutations. Since then, there has been widespread discussion about bexarotene, as well as a number of follow-up studies. Bexarotene is a unique compound, as it is approve ...[more]