The molecular basis of rectal cancer.

ABSTRACT: The majority of rectal carcinomas are sporadic in nature, and relevant testing for driver mutations to guide therapy is important. A thorough family history is necessary and helpful in elucidating a potential hereditary predilection for a patient's carcinoma. The adequate diagnosis of a heritable tendency toward colorectal carcinoma alters the management of a patient disease and permits the implementation of various surveillance algorithms as preventive measures.

SUBMITTER: Shiller M 

PROVIDER: S-EPMC4336907 | biostudies-other | 2015 Mar

REPOSITORIES: biostudies-other