Unknown

Dataset Information

0

Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.


ABSTRACT: Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and systemic infections. Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C. albicans. Systemic immunity is considered T cell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C. albicans. We found that only yeast induced Th17 cell responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by Langerhans cells. Filamentous forms induced Th1 without Th17 cell responses due to the absence of Dectin-1 ligation. Notably, Th17 cell responses provided protection against cutaneous infection while Th1 cell responses provided protection against systemic infection. Thus, C. albicans morphology drives distinct T helper cell responses that provide tissue-specific protection. These findings provide insight into compartmentalization of Th cell responses and C. albicans pathogenesis and have critical implications for vaccine strategies.

SUBMITTER: Kashem SW 

PROVIDER: S-EPMC4343045 | biostudies-other | 2015 Feb

REPOSITORIES: biostudies-other

altmetric image

Publications


Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and systemic infections. Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C. albicans. Systemic immunity is considered T cell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C. albicans. We found that only yeast induced Th17 cell responses through a mechanism that r  ...[more]

Similar Datasets

| S-EPMC2626749 | biostudies-literature
| S-EPMC8585696 | biostudies-literature
| S-EPMC4023883 | biostudies-other
| S-EPMC2459306 | biostudies-literature
| S-EPMC3163010 | biostudies-literature
| S-EPMC3564527 | biostudies-literature
| S-EPMC5673188 | biostudies-literature
| S-EPMC5413322 | biostudies-literature
| S-EPMC3664066 | biostudies-literature
| S-EPMC5992276 | biostudies-literature