Ontology highlight
ABSTRACT:
SUBMITTER: Chen CY
PROVIDER: S-EPMC43434 | biostudies-other | 1994 Mar
REPOSITORIES: biostudies-other
Chen C Y CY Oliner J D JD Zhan Q Q Fornace A J AJ Vogelstein B B Kastan M B MB
Proceedings of the National Academy of Sciences of the United States of America 19940301 7
Normal p53 function is required for optimal arrest of cells in the G1 phase of the cell cycle following certain types of DNA damage. Loss of this cell cycle checkpoint may contribute to tumor development by increasing the number of genetic abnormalities in daughter cells following DNA damage. The MDM2 protein is an endogenous gene product that binds to the p53 protein and is able to block p53-mediated transactivation of cotransfected reporter constructs; thus, interactions between MDM2 and p53 i ...[more]