Ontology highlight
ABSTRACT:
SUBMITTER: Martasek P
PROVIDER: S-EPMC43507 | biostudies-other | 1994 Apr
REPOSITORIES: biostudies-other
Martasek P P Camadro J M JM Delfau-Larue M H MH Dumas J B JB Montagne J J JJ de Verneuil H H Labbe P P Grandchamp B B
Proceedings of the National Academy of Sciences of the United States of America 19940401 8
Coproporphyrinogen oxidase (EC 1.3.3.3) catalyzes the sixth step in the heme biosynthetic pathway, the oxidation of coproporphyrinogen III to protoporphyrinogen IX. The activity of this enzyme is deficient in the disease hereditary coproporphyria. The sequence of the cDNA and predicted amino acid sequence of the human coproporphyrinogen oxidase are presented. The human protein sequence contains a region completely homologous to that we obtained by sequencing an 11-amino acid peptide fragment fro ...[more]