Ontology highlight
ABSTRACT:
SUBMITTER: Roychoudhury J
PROVIDER: S-EPMC4400291 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Roychoudhury Jayeeta J Clark Jason P JP Gracia-Maldonado Gabriel G Unnisa Zeenath Z Wunderlich Mark M Link Kevin A KA Dasgupta Nupur N Aronow Bruce B Huang Gang G Mulloy James C JC Kumar Ashish R AR
Blood 20150304 16
Leukemias with MLL translocations are often found in infants and are associated with poor outcomes. The pathogenesis of MLL-fusion leukemias has been linked to upregulation of HOX/MEIS1 genes. The functions of the Hox/Meis1 complex in leukemia, however, remain elusive. Here, we used inducible Meis1-knockout mice coupled with MLL-AF9 knockin mice to decipher the mechanistic role of Meis1 in established MLL leukemia. We demonstrate that Meis1 is essential for maintenance of established leukemia. I ...[more]