Ontology highlight
ABSTRACT:
SUBMITTER: Iwabuchi K
PROVIDER: S-EPMC44145 | biostudies-other | 1994 Jun
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19940601 13
p53 is a tumor-suppressor protein that can activate and repress transcription. Using the yeast two-hybrid system, we identified two previously uncharacterized human proteins, designated 53BP1 and 53BP2, that bind to p53. 53BP1 shows no significant homology to proteins in available databases, whereas 53BP2 contains two adjacent ankyrin repeats and a Src homology 3 domain. In vitro binding analyses indicate that both of these proteins bind to the central domain of p53 (residues 80-320) required fo ...[more]