Ontology highlight
ABSTRACT:
SUBMITTER: Chiara MD
PROVIDER: S-EPMC44210 | biostudies-other | 1994 Jul
REPOSITORIES: biostudies-other
Chiara M D MD Champion-Arnaud P P Buvoli M M Nadal-Ginard B B Reed R R
Proceedings of the National Academy of Sciences of the United States of America 19940701 14
Spliceosome-associated proteins (SAPs) 61, 62, and 114 can be UV-crosslinked to pre-mRNA in purified spliceosomal complexes and are associated with U2 small nuclear ribonucleoproteins (snRNP). These proteins also compose the essential heterotrimeric splicing factor SF3a, and products of yeast pre-mRNA processing genes PRP9, PRP11, and PRP21 are their likely yeast counterparts. We report the isolation of a cDNA encoding SAP 61 and find that it is 30% identical in amino acid sequence to PRP9. A C- ...[more]