Ontology highlight
ABSTRACT:
SUBMITTER: Braidy N
PROVIDER: S-EPMC4424846 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Frontiers in cellular neuroscience 20150508
Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. Our data shows that SIRT1 expression increases with age, concurrently with increased ...[more]