Ontology highlight
ABSTRACT:
SUBMITTER: Ambler BR
PROVIDER: S-EPMC4433581 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Organic letters 20150424 10
"Cu-CF3" species have been used historically for a broad spectrum of nucleophilic trifluoromethylation reactions. Although recent advancements have employed ligands to stabilize and harness the reactivity of this key organometallic intermediate, the ability of a ligand to differentiate a regiochemical outcome of a Cu-CF3-mediated or -catalyzed reaction has not been previously reported. Herein, we report the first example of a Cu-catalyzed trifluoromethylation reaction in which a ligand controls ...[more]