Ontology highlight
ABSTRACT:
SUBMITTER: Tseng SH
PROVIDER: S-EPMC4445874 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Tseng Shih-Heng SH Chou Min-Yuan MY Chu I-Ming IM
International journal of nanomedicine 20150520
We have developed a theranostic nanoparticle, ie, cet-PEG-dexSPIONs, by conjugation of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody, cetuximab, to dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) via periodate oxidation. Approximately 31 antibody molecules were conjugated to each nanoparticle. Cet-PEG-dexSPIONs specifically bind to EGFR-expressing tumor cells and enhance image contrast on magnetic resonance imaging. Cet-PEG-dexSPION-treated A431 cells sh ...[more]