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A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.

ABSTRACT: Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

SUBMITTER: Lincoln KM

PROVIDER: S-EPMC4446701 | biostudies-other | 2013 Apr

REPOSITORIES: biostudies-other

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A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.

Lincoln Kimberly M KM Gonzalez Paulina P Richardson Timothy E TE Julovich David A DA Saunders Ryker R Simpkins James W JW Green Kayla N KN

Chemical communications (Cambridge, England) 20130401 26

Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character. ...[more]

PMID: 23437435

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