Desmosomes in acquired disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Stahley SN
PROVIDER: S-EPMC4456195 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Publications
Desmosomes in acquired disease.
Stahley Sara N SN Kowalczyk Andrew P AP
Cell and tissue research 20150321 3
Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement integrates adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, which occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In additio ...[more]
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