Ontology highlight
ABSTRACT:
SUBMITTER: Colombe JR
PROVIDER: S-EPMC4477900 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Colombe James R JR DeBergh J Robb JR Buchwald Stephen L SL
Organic letters 20150611 12
A method for the preparation of aryl and heteroaryl sulfonamides using 2,4,6-trichlorophenyl chlorosulfate (TCPC) is described. The reaction of 2-pyridylzinc reagents with TCPC resulted in 2,4,6-trichlorophenyl (TCP) pyridine-2-sulfonates, and the parent pyridine-2-sulfonate was shown to react with amines. Less electron-rich aryl- and heteroarylzinc reagents reacted with TCPC to afford sulfonyl chlorides that were converted in situ to sulfonamides. ...[more]