Ontology highlight
ABSTRACT:
SUBMITTER: Bhatia S
PROVIDER: S-EPMC4496193 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Bhatia Shilpa S Baig Nimrah A NA Timofeeva Olga O Pasquale Elena B EB Hirsch Kellen K MacDonald Tobey J TJ Dritschilo Anatoly A Lee Yi Chien YC Henkemeyer Mark M Rood Brian B Jung Mira M Wang Xiao-Jing XJ Kool Marcel M Rodriguez Olga O Albanese Chris C Karam Sana D SD
Oncotarget 20150401 11
The expression of members of the Eph family of receptor tyrosine kinases and their ephrin ligands is frequently dysregulated in medulloblastomas. We assessed the expression and functional role of EphB1 in medulloblastoma cell lines and engineered mouse models. mRNA and protein expression profiling showed expression of EphB1 receptor in the human medulloblastoma cell lines DAOY and UW228. EphB1 downregulation reduced cell growth and viability, decreased the expression of important cell cycle regu ...[more]