Ontology highlight
ABSTRACT:
SUBMITTER: Sashidhara KV
PROVIDER: S-EPMC4499817 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20150529 7
A series of novel hybrids possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against Staphylococcus aureus, and in particular, compound 27 exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound 27 was nonhemolytic and nontoxic to mammalian cells. The in vivo studies utilizing a S. aureus s ...[more]