Ontology highlight
ABSTRACT:
SUBMITTER: Chen JH
PROVIDER: S-EPMC4502816 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Chen Jing-Hong JH Zhang Peng P Chen Wen-Dan WD Li Dan-Dan DD Wu Xiao-Qi XQ Deng Rong R Jiao Lin L Li Xuan X Ji Jiao J Feng Gong-Kan GK Zeng Yi-Xin YX Jiang Jian-Wei JW Zhu Xiao-Feng XF
Autophagy 20150101 2
PTEN (phosphatase and tensin homolog), a tumor suppressor frequently mutated in human cancer, has various cytoplasmic and nuclear functions. PTEN translocates to the nucleus from the cytoplasm in response to oxidative stress. However, the mechanism and function of the translocation are not completely understood. In this study, topotecan (TPT), a topoisomerase I inhibitor, and cisplatin (CDDP) were employed to induce DNA damage. The results indicate that TPT or CDDP activates ATM (ATM serine/thre ...[more]