Ontology highlight
ABSTRACT:
SUBMITTER: Yabumoto C
PROVIDER: S-EPMC4585890 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Yabumoto Chizuru C Akazawa Hiroshi H Yamamoto Rie R Yano Masamichi M Kudo-Sakamoto Yoko Y Sumida Tomokazu T Kamo Takehiro T Yagi Hiroki H Shimizu Yu Y Saga-Kamo Akiko A Naito Atsuhiko T AT Oka Toru T Lee Jong-Kook JK Suzuki Jun-Ichi J Sakata Yasushi Y Uejima Etsuko E Komuro Issei I
Scientific reports 20150925
Disruption of angiotensin II type 1 (AT1) receptor prolonged life span in mice. Since aging-related decline in skeletal muscle function was retarded in Atgr1a(-/-) mice, we examined the role of AT1 receptor in muscle regeneration after injury. Administration of AT1 receptor blocker irbesartan increased the size of regenerating myofibers, decreased fibrosis, and enhanced functional muscle recovery after cryoinjury. We recently reported that complement C1q, secreted by macrophages, activated Wnt/β ...[more]