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β3-adrenoreceptor and tumor microenvironment: a new hub.


ABSTRACT: The achievement of malignant traits in several cancers is associated with tumor microenvironment reactivity. New evidence show that the stress hormone noradrenaline enhances melanoma microenvironment reactivity, mainly acting through β3-adrenoreceptors (β2-ARs), favoring recruitment of cancer-associated fibroblasts, M2-macrophages, bone marrow-derived precursors, These events concur in sustaining a pro-inflammatory and pro-angiogenic milieu, finally boosting melanoma malignancy.

SUBMITTER: Chiarugi P 

PROVIDER: S-EPMC4589043 | biostudies-other | 2015 Nov

REPOSITORIES: biostudies-other

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