Ontology highlight
ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC6943458 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhu Chen C Kong Ziqing Z Wang Biao B Cheng Wen W Wu Anhua A Meng Xin X
American journal of translational research 20191215 12
β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 participates in reprogramming tumor metabolism, shaping the stromal and immune microenvironment, facilitating epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (End-MT) and maintaining tumor stemness, etc. Recent studies proposed various intervention strategies against ITGB3 and have achieved pr ...[more]